DTU iGEM Team 2020: RESHAPE
We RESHAPE mycelial morphology in filamentous fungi to aid industrial production of proteins and small molecules. This is done by identifying genetic targets in Aspergillus niger which can be engineered in most industrially relevant strains of the species using synthetic biology.
We also develop novel signal peptides to improve protein secretion in A. niger. Finally we develop software tools which may predict morphology patterns of filamentous fungi and create synthetic signal peptides which can increase protein secretion levels. Improving the efficiency of bio-based production processes will provide economic incentives to use them. In this way, we can decrease our reliance on oil-based substrates and move towards a more sustainable and bio-based future.
We also develop novel signal peptides to improve protein secretion in A. niger. Finally we develop software tools which may predict morphology patterns of filamentous fungi and create synthetic signal peptides which can increase protein secretion levels. Improving the efficiency of bio-based production processes will provide economic incentives to use them. In this way, we can decrease our reliance on oil-based substrates and move towards a more sustainable and bio-based future.